Biventricular Deformation Recovery from Cine MRI
We have developed a method for biventricular myocardial deformation recovery from cine MRI. The method is based on a deformable model that is nearly incompressible, a desirable property since the myocardium has been shown to be nearly incompressible. The model uses a representation that allows for deformation modeling of an arbitrary topology with a relatively small number of parameters, which is suitable for representing the motion of the multi-chamber structure of the heart. The myocardium needs to be segmented in an initial frame after which the method automatically determines the tissue deformation everywhere in the myocardium throughout the cardiac cycle. Fig. 1 demonstrates the types of deformation that the model can generate.
Once the 3D myocardial displacement field is recovered, one can directly compute myocardial strain. Fig. 2 shows radial and circumferential strain of a normal subject in a short axis slice over the cardiac cycle.
To validate the method, we compared the deformation recovered from a 3-D anatomical cine MRI to the myocardial displacement obtained from corresponding 3-D tagged cine MRI. The average distance between the model and manually determined intersections of perpendicular tag planes was 1.2 pixel. This is illustrated in Fig. 3.
 Bistoquet, A., Oshinski, J., Skrinjar, O., "Myocardial Deformation Recovery from Cine MRI Using a Nearly Incompressible Biventricular Model", Medical Image Analysis, 12(1): 69-85, February 2008. LINK